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Metabolic enzymes as potential drug targets in Plasmodium falciparum.

Subbayya, IN and Ray, SS and Balaram, P and Balaram, H (1997) Metabolic enzymes as potential drug targets in Plasmodium falciparum. In: Indian Journal of Medical Research, 106 . pp. 79-94.

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Plasmodium falciparum causes the most severe form of malaria that is fatal in many cases. Emergence of drug resistant strains of P. falciparum requires that new drug targets be-identified. This review considers in detail enzymes of the glycolytic pathway, purine salvage pathway, pyrimidine biosynthesis and proteases involved in catabolism of haemoglobin. Structural features of P. falciparum triosephosphate isomerase which could be exploited for parasite specific drug development have been highlighted. Utility of P. falciparum hypoxanthine-guanine-phosphoribosyltransferase, adenylosuccinate synthase, dihydroorotate dehydrogenase, thymidylate synthase-dihydrofolate reductase, cysteine and aspartic proteases have been elaborated in detail. The review also briefly touches upon other potential targets in P. falciparum

Item Type: Journal Article
Publication: Indian Journal of Medical Research
Publisher: Indian Council of Medical Research
Additional Information: Copy right of this article belongs to Indian Council of Medical Research.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 30 Apr 2010 05:36
Last Modified: 19 Sep 2010 06:00
URI: http://eprints.iisc.ac.in/id/eprint/27367

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