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Identification of protein interaction regions of VINC/NEAT1/Men epsilon RNA

Murthy, Sreenivasa UM and Rangarajan, Pundi N (2010) Identification of protein interaction regions of VINC/NEAT1/Men epsilon RNA. In: FEBS Letters, 584 (8). pp. 1531-1535.

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Official URL: http://dx.doi.org/10.1016/j.febslet.2010.03.003


The virus inducible non-coding RNA (VINC) was detected initially in the brain of mice infected with Japanese encephalitis virus (JEV) and rabies virus. VINC is also known as NEAT1 or Men epsilon RNA. It is localized in the nuclear paraspeckles of several murine as well as human cell lines and is essential for paraspeckle formation. We demonstrate that VINC interacts with the paraspeckle protein, P54nrb through three different protein interaction regions (PIRs) one of which (PIR-1) is localized near the 50 end while the other two (PIR-2, PIR-3) are localized near the 30 region of VINC. Our studies suggest that VINC may interact with P54nrb through a novel mechanism which is different from that reported for protein coding RNAs. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: VINC; NEAT1; Men epsilon RNA; Non-coding RNA; Paraspeckle; P54nrb
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Apr 2010 08:44
Last Modified: 19 Sep 2010 06:00
URI: http://eprints.iisc.ac.in/id/eprint/27259

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