Host factor Ebp1 inhibits rinderpest virus transcription in vivo

Gopinath, M and Raju, S and Honda, A and Shaila, MS (2010) Host factor Ebp1 inhibits rinderpest virus transcription in vivo. In: Archives of Virology, 155 (4). pp. 455-462.

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Abstract

ErbB3 binding protein Ebp1 has been shown to downregulate ErbB3 receptor-mediated signaling to inhibit cell proliferation. Rinderpest virus belongs to the family Paramyxoviridae and is characterized by the presence of a non-segmented negative-sense RNA genome. In this work, we show that rinderpest virus infection of Vero cells leads to the down-regulation of the host factor Ebp1, at both the mRNA and protein levels. Ebp1 protein has been shown to co-localize with viral inclusion bodies in infected cells, and it is packaged into virions, presumably through its interaction with the N protein or the N-RNA itself. Overexpression of Ebp1 inhibits viral transcription and multiplication in infected cells, suggesting that a mutual antagonism operates between host factor Ebp1 and the virus.

Item Type:	Journal Article
Publication:	Archives of Virology
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	09 Jun 2010 04:42
Last Modified:	19 Sep 2010 06:00
URI:	http://eprints.iisc.ac.in/id/eprint/27143

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