Structure and Dynamics of a Molecular Hydrogel Derived from a Tripodal Cholamide

Mukhopadhyay, Samrat and Maitra, Uday and Ira, * and Krishnamoorthy, Guruswamy and Schmidt, Judith and Talmon, Yeshayahu (2004) Structure and Dynamics of a Molecular Hydrogel Derived from a Tripodal Cholamide. In: Journal of The American Chemical Society, 126 (48). pp. 15905-15914.

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Abstract

Tripodal cholamide 1 is a supergelator of aqueous fluids. A variety of physical techniques, including cryo-transmission electron microscopy (TEM), circular dichroism (CD), steady-state fluorescence, time-resolved fluorescence, and dynamic light-scattering, were employed to understand the structure and dynamics of the gel. Fluorescent probes [ANS (8-anilinonaphthalene-1-sulfonic acid) and pyrene] reported two critical aggregation concentrations $(CAC_1 and CAC_2)$ of 1 in predominantly aqueous media, with the minimum gel concentration (MGC) being close to $CAC_2$. Fluorescence lifetime measurements with pyrene revealed ineffective quenching of pyrene fluorescence by oxygen, possibly caused by slower Brownian diffusion due to the enhanced viscosity in the gel phase. The study of the gelation kinetics by monitoring the ultrafast dynamics of ANS revealed a progressive increase in the aggregate size and the microviscosity of the aqueous pool encompassed by the self-assembled fibrillar network (SAFIN) during the gelation. The striking difference between microviscosity and bulk (macroscopic) viscosity of the gel is also discussed.lifetime measurements with pyrenerevealed ineffective quenching of pyrene fluorescence by oxygen,possibly caused by slower Brownian diffusion due to the enhancedviscosity in the gel phase. The study of the gelation kinetics bymonitoring the ultrafast dynamics of ANS revealed a progressiveincrease in the aggregate size and the microviscosity of the aqueouspool encompassed by the self-assembled fibrillar network (SAFIN) duringthe gelation. The striking difference between microviscosity and bulk(macroscopic) viscosity of the gel is also discussed.

Item Type:	Journal Article
Publication:	Journal of The American Chemical Society
Publisher:	American Chemical society
Additional Information:	The copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	03 Feb 2005
Last Modified:	19 Jan 2012 07:00
URI:	http://eprints.iisc.ac.in/id/eprint/2706

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