Non-segmented negative sense RNA viruses as vectors for vaccine development

Suryanarayana, VVS and Chattopadhyay, Dhrubajyothi and Shaila, MS (2010) Non-segmented negative sense RNA viruses as vectors for vaccine development. In: Current Science (Bangalore), 98 (3). pp. 379-391.

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Abstract

This article intends to cover two aspects of non-segmented negative sense RNA viruses. In the initial section, the strategy employed by these viruses to replicate their genomes is discussed. This would help in understanding the later section in which the use of these viruses as vaccine vectors has been discussed. For the description of the replication strategy which encompasses virus genome transcription and genome replication carried out by the same RNA dependent RNA polymerase complex, a member of the prototype rhabdovirus family - Chandipura virus has been chosen as an example to illustrate the complex nature of the two processes and their regulation. In the discussion on these viruses serving as vectors for carrying vaccine antigen genes, emphasis has been laid on describing the progress made in using the attenuated viruses as vectors and a description of the systems in which the efficiency of immune responses has been tested.

Item Type:	Journal Article
Publication:	Current Science (Bangalore)
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Chandipura virus; chimeric viruses; non-segmented negative sense RNA viruses; vaccine vectors; virus replication
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	12 Apr 2010 08:13
Last Modified:	19 Sep 2010 05:59
URI:	http://eprints.iisc.ac.in/id/eprint/27046

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