Japanese encephalitis: pathogenesis, prophylactics and therapeutics

Dutta, Kallol and Rangarajan, Pundi N and Vrati, Sudhanshu and Basu, Anirban (2010) Japanese encephalitis: pathogenesis, prophylactics and therapeutics. In: Current Science (Bangalore), 98 (3). pp. 326-334.

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Abstract

Japanese encephalitis (JE) is one of the most dreaded mosquito-borne viral encephalitis known to afflict humans. The Japanese encephalitis virus (JEV) is a neurotropic flavivirus that affects the CNS, causing extensive damage that may lead to fatality in about one third of bpatients. Half of the survivors suffer from severe neuropshychiatric sequelae. With nearly 3 billion people living under the current JE-endemic region, recurring incidents of epidemic are being reported at regular intervals. With no established antiviral therapies against JE available, vaccination has been the only way of preventing JE. Two types of JE vaccines are currently in vogue although the safety of administering them is questionable, in certain individuals. Thus, there is a need to develop a safe, affordable and potent JE vaccine and this review addresses the current efforts in this direction. This review also focuses on the pathophysiology of JE and efforts towards a possible breakthrough in anti-JEV therapy.

Item Type:	Journal Article
Publication:	Current Science (Bangalore)
Publisher:	Indian Academy of Sciences
Keywords:	Central neurons system; flavivirus; Japanese encephalitis virus; prophylaxis; vaccine
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	12 Apr 2010 08:08
Last Modified:	19 Sep 2010 05:59
URI:	http://eprints.iisc.ac.in/id/eprint/27043

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