Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides

Gangadhar, Vidya and Jeyakani, Justin J and Shaila, MS and Nayak, Rabindranath and Chandra, Nagasuma (2007) Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides. In: Biochemical and Biophysical Research Communications, 364 (2). pp. 308-312.

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Abstract

Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation. (C)) 2007 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Information Sciences (Doesn't exist now) > BioInformatics Centre Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	09 Jun 2010 08:45
Last Modified:	19 Sep 2010 05:59
URI:	http://eprints.iisc.ac.in/id/eprint/26805

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