Mehta, Goverdhan and Umarye, Jayant D (2002) Studies toward the Total Synthesis of Diterpene Antibiotic Guanacastepene A: Construction of the Hydroazulenic Core. In: Organic Letters, 4 (7). pp. 1063-1066.
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Abstract
As a part of studies aimed toward the total synthesis of biologically important natural product guanacastepene A of contemporary interest,a new and concise route to a fully functionally endowed hydroazulenic core is delineated. The strategy involves the building of the requisite stereochemical features on a endo-tricyclo[5.2.1.02,6]decane matrix and excision of the five-membered ring through a retro-Diels-Alder reaction.Generation of the seven-membered ring to access the hydroazulenic framework was achieved employing ring closure metathesis (RCM)reaction as the key step.
Item Type: | Journal Article |
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Publication: | Organic Letters |
Publisher: | American Chemical Society |
Additional Information: | Copyright for this article belongs to American Chemical Society. |
Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
Date Deposited: | 24 Jan 2005 |
Last Modified: | 19 Jan 2012 06:03 |
URI: | http://eprints.iisc.ac.in/id/eprint/2676 |
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