Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF-β1

Arany, Praveen R (2008) Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF-β1. In: 2nd International Engineering Conference on Light-Activated Tissue Regeneration and Therapy, JUN 24-29, 2007, Tomar.

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Abstract

Laser mediated stimulation of biological process was amongst its very first effects documented by Mester et al. but the ambiguous and tissue-cell context specific biological effects of laser radiation is now termed ‘Photobiomodulation’. We found many parallels between the reported biological effects of lasers and a multiface-ted growth factor, Transforming Growth Factor-β (TGF-β). This review outlines the interestingparallelsbetween the twofieldsand our rationalefor pursuingtheir potential causal correlation. We explored this correlation using an in vitro assay systems and a human clinical trial on healing wound extraction sockets that we reported in a recent publication. In conclusion we report that low power laser irradiation can activate latent TGF-β1 and β3 complexes and suggest that this might be one of the major modes of the photobiomodulatory effects of low power lasers.

Item Type:	Conference Paper
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	Low power laser therapy;photobiomodulation;latent;TGF;beta1 activation;laser medicine;wound healing;oral wounds;redox sensing.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	29 Mar 2010 11:43
Last Modified:	19 Sep 2010 05:58
URI:	http://eprints.iisc.ac.in/id/eprint/26673

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