Medrano-Soto, Arturo and Pal, Debnath and Eisenberg, David (2008) Inferring molecular function: contributions from functional linkages. In: Trends in Genetics, 24 (12). 587 -590.
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Abstract
In the current era of high-throughput sequencing and structure determination, functional annotation has become a bottleneck in biomedical science. Here, we show that automated inference of molecular function using functional linkages among genes increases the accuracy of functional assignments by >= 8% and enriches functional descriptions in >= 34% of top assignments. Furthermore, biochemical literature supports >80% of automated inferences for previously unannotated proteins. These results emphasize the benefit of incorporating functional linkages in protein annotation.
Item Type: | Journal Article |
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Publication: | Trends in Genetics |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Department/Centre: | Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre Division of Information Sciences (Doesn't exist now) > BioInformatics Centre |
Date Deposited: | 23 Mar 2010 12:03 |
Last Modified: | 19 Sep 2010 05:58 |
URI: | http://eprints.iisc.ac.in/id/eprint/26486 |
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