Conformationally locked thiosugars alpha-mannosidase inhibitors: Synthesis, and docking studies as potent biochemical

Slvapriya, K and Hariharaputran, S and Suhas, VL and Chandra, N and Chandrasekaran, Srinivasan (2007) Conformationally locked thiosugars alpha-mannosidase inhibitors: Synthesis, and docking studies as potent biochemical. In: Bioorganic & Medicinal Chemistry, 15 (17). pp. 5659-5665.

PDF cf.pdf - Published Version Restricted to Registered users only Download (663kB) | Request a copy

Abstract

series of thiosugar derivatives (thiolevomannosans) derived from mannose were synthesized and their inhibitory activity was tested against alpha-mannosidase (jack bean). These inhibitors were found to be more potent than the well-known inhibitors like kifunensine and deoxymannojirimycin based on docking and biochemical studies. The sulfone derivative 10 was shown to be the best inhibitor of alpha-mannosidase with the K-i value of 350 nM. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	Bioorganic & Medicinal Chemistry
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre Division of Chemical Sciences > Organic Chemistry
Date Deposited:	10 Jun 2010 10:33
Last Modified:	19 Sep 2010 05:57
URI:	http://eprints.iisc.ac.in/id/eprint/26220

Actions (login required)

View Item