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Asymmetric allylic alkylation by palladium-bisphosphinites

Sharma, Rakesh K and Nethaji, Munirathnam and Samuelson, Ashoka G (2008) Asymmetric allylic alkylation by palladium-bisphosphinites. In: Tetrahedron: Asymmetry, 19 (6). pp. 655-663.

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A series of new chiral palladium-bisphosphinite complexes have been prepared from readily available, naturally occurring chiral alcohols. The complexes were used to efficiently carry out catalytic allylic alkylation of 1,3-diphenylpropene-2-yl acetate with dimethyl malonate. The complexes based on derivatives of ascorbic acid carry out enantioselective alkylations, one of which showed an ee as high as 97%. Based on the structural characterization, it can be surmised that strategic placement of phenyl groups is key to higher enantioselectivities.

Item Type: Journal Article
Publication: Tetrahedron: Asymmetry
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 08 Mar 2010 10:45
Last Modified: 19 Sep 2010 05:56
URI: http://eprints.iisc.ac.in/id/eprint/25937

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