Membrane modifying linear polypeptide antibiotics

Nagaraj, R and Balaram, P (1980) Membrane modifying linear polypeptide antibiotics. In: Proceedings of the Indian National Science Academy . pp. 199-218.

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Abstract

Peptides Possessing antibiotic activity isolated from microbial sources have been the subject of intensive structural and biological investigation over the past two decades. Perhaps, the discovery and widespread use of penicillin, a molecule biosynthetically derived from a tripeptide precursor, as a strong antibacterial agent, has provided the necessary impetus for the detailed study of microbial peptides. While many of these peptides have not been used clinically, They show unique metal binding properties and often possess the ability to modify the electrical properties or ion permeabilities of artificial lipid membranes. Hence, these peptides have been used extensively to study transmembrane ion transport processes in model and natural systems like mitochondria, chloroplasts and plasma membranes.

Item Type:	Journal Article
Publication:	Proceedings of the Indian National Science Academy
Publisher:	Indian National Science Academy
Additional Information:	Copyright of this article belongs to Indian National Science Academy.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	22 Feb 2010 09:04
Last Modified:	19 Sep 2010 05:55
URI:	http://eprints.iisc.ac.in/id/eprint/25644

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