Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase

Bakshi, RP and Galande, S and Muniyappa, K (2001) Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase. In: Critical Reviews in Biochemistry and Molecular Biology, 36 (1). pp. 1-37.

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Abstract

DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism. Type II DNA topoisomerase (topo II) is vital for various nuclear processes, including DNA replication, chromosome segregation, and maintenance of chromosome structure. Topo II expression is regulated at multiple stages, including transcriptional, posttranscriptional, and posttranslational levels, by a multitude of signaling factors. Topo II is also the cellular target for a variety of clinically relevant anti-tumor drugs. Despite significant progress in our understanding of the role of topo II in diverse nuclear processes, several important aspects of topo II function, expression, and regulation are poorly understood. We have focused this review specifically on eukaryotic DNA topoisomerase II, with an emphasis on functional and regulatory characteristics.

Item Type:	Journal Article
Publication:	Critical Reviews in Biochemistry and Molecular Biology
Publisher:	Taylore and Francis
Additional Information:	Copyright of this article belongs to Taylore and Francis.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	22 Feb 2010 09:40
Last Modified:	19 Sep 2010 05:55
URI:	http://eprints.iisc.ac.in/id/eprint/25637

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