Mycobacterial Stress Regulation: The Dps ``Twin Sister'' Defense Mechanism and Structure-Function Relationship

Chowdhury, Rakhi Pait and Saraswathi, Ramachandran and Chatterji, Dipankar (2010) Mycobacterial Stress Regulation: The Dps ``Twin Sister'' Defense Mechanism and Structure-Function Relationship. In: IUBMB Life, 62 (1). pp. 67-77.

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Abstract

In this work, we have tried to emphasize the connection between mycobacterial growth and regulation of gene expression. Utilization of multiple carbon sources and diauxic growth helps bacteria to regulate gene expression at an optimum level so that the inhospitable conditions encountered during nutrient depletion can be circumvented. These aspects will be discussed with respect to mycobacterial growth in subsequent sections. Identification and characterization of genes induced under such conditions is helpful to understand the physiology of the bacterium. Although it is necessary to compare the total expression profile of proteins as they transit from vegetative growth to stationary phase, at times a lot of insights can be deciphered from the expression pattern of one or two proteins. We have compared the protein expression and sigma factor selectivity of two such proteins in M. smegmatis to understand the differential regulation of genes playing diverse function in the same species. Some newer insights on the structure and function of one of the Dps proteins are also explained.

Item Type:	Journal Article
Publication:	IUBMB Life
Publisher:	John wiley and sons
Additional Information:	Copyright for this article belongs to John wiley and sons.
Keywords:	Dps; transcriptional regulation; DNA binding; interface cluster analysis; stress response
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	02 Feb 2010 10:27
Last Modified:	19 Sep 2010 05:54
URI:	http://eprints.iisc.ac.in/id/eprint/25485

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