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Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

Basu, Nirmalya and Arshad, Najla and Visweswariah, Sandhya S (2010) Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. In: Molecular and Cellular Biochemistry, 334 (1-2). pp. 67-80.

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Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin, and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of expression of GC-C is in the gastrointestinal tract, although this receptor and its ligands play a role in ion secretion in other tissues as well. GC-C shares the domain organization seen in other members of the family of receptor guanylyl cyclases, though subtle differences highlight some of the unique features of GC-C. Gene knock outs in mice for GC-C or its ligands do not lead to embryonic lethality, but modulate responses of these mice to stable toxin peptides, dietary intake of salts, and development and differentiation of intestinal cells. It is clear that there is much to learn in future about the role of this evolutionarily conserved receptor, and its properties in intestinal and extra-intestinal tissues.

Item Type: Journal Article
Publication: Molecular and Cellular Biochemistry
Publisher: Springer
Additional Information: Copyright for this article belongs to Springer.
Keywords: Guanylyl cyclase C; Guanylin; Uroguanylin; Stable toxin peptides; cGMP
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 02 Feb 2010 07:17
Last Modified: 19 Sep 2010 05:54
URI: http://eprints.iisc.ac.in/id/eprint/25478

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