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Prevalence of multidrug-resistant Staphylococcus aureus in diabetics clinical samples

Raju, S and Oli, Ajay Kumar and Patil, SA and Chandrakanth, R Kelmani (2010) Prevalence of multidrug-resistant Staphylococcus aureus in diabetics clinical samples. In: World Journal of Microbiology and Biotechnology, 26 (1). pp. 171-176. (In Press)

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Antibiotic resistance in 40 Staphylococcus aureus clinical isolates from 110 diabetic patients (36%) was evaluated. Of these, 32 (80%) of the isolates showed multidrug-resistance to more than eight antibiotics and 35% isolates were found to be methicillin resistant S. aureus (MRSA). All 40 S. aureus strains (100%) screened from diabetic clinical specimens were resistant to penicillin, 63% to ampicillin, 55% to streptomycin, 50% to tetracycline and 50% to gentamicin. Where as low resistance rate was observed to ciprofloxacin (20%) and rifampicin (8%). In contrast, all (100%) S. aureus strains recorded susceptibility to teicoplanin, which was followed by vancomycin (95%). Genotypical examination revealed that 80% of the aminoglycoside resistant S. aureus (ARSA) have aminoglycoside modifying enzyme (AME) coding genes; however, 20% of ARSA which showed non-AME mediated (adaptive) aminoglycoside resistance lacked these genes in their genome. In contrast all MRSA isolates possessed mecA, femA genetic determinants in their genome.

Item Type: Journal Article
Publication: World Journal of Microbiology and Biotechnology
Publisher: Springer
Additional Information: Copyright for this article belongs to Springer.
Keywords: Methicillin resistant Staphylococcus aureus; Aminoglycoside modifying enzymes; mecA and femA
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 02 Feb 2010 07:17
Last Modified: 19 Sep 2010 05:54
URI: http://eprints.iisc.ac.in/id/eprint/25473

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