Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures

Swain, Monalisa and Thirupathi, R and Krishnarjuna, B and Eaton, Erin M and Kibbey, Megan M and Rosenzweig, Steven A and Atreya, Hanudatta S (2010) Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures. In: Chemical Communication, 46 (2). pp. 216-218.

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Abstract

In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.

Item Type:	Journal Article
Publication:	Chemical Communication
Publisher:	Royal Society Chemistry
Additional Information:	Copyright for this article belongs to Royal Society Chemistry.
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	05 Jan 2010 10:51
Last Modified:	19 Sep 2010 05:54
URI:	http://eprints.iisc.ac.in/id/eprint/25340

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