Synthesis of Thioesters by Simultaneous Activation of Carboxylic Acids and Alcohols Using PPh3/NBS with Benzyltriethylammonium Tetrathiomolybdate as the Sulfur Transfer Reagent

Gopinath, Purushothaman and Vidyarini, Ravindran Sasitha and Chandrasekaran, Srinivasan (2009) Synthesis of Thioesters by Simultaneous Activation of Carboxylic Acids and Alcohols Using PPh3/NBS with Benzyltriethylammonium Tetrathiomolybdate as the Sulfur Transfer Reagent. In: European Journal of Organic Chemistry (34). pp. 6043-6047.

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Abstract

A new and simple route for the synthesis of thioesters starting from carboxylic acids and alcohols is reported by using tetrathiomolybdate as the key sulfur transfer reagent. Triphenylphosphane and N-bromosuccinimide were used for the activation of the carboxylic acid and alcohol in the same pot followed by the transfer of sulfur from tetrathiomolybdate. Thioesters were obtained in good to moderate yields. Primary alcohols show excellent reactivity and gave good yields of the corresponding thioesters, whereas secondary alcohols gave moderate yields and tertiary alcohols were very less reactive and gave poor yields of the corresponding thioesters.

Item Type:	Journal Article
Publication:	European Journal of Organic Chemistry
Publisher:	John Wiley and Sons
Additional Information:	copyright of this article belongs to John Wiley and Sons.
Keywords:	Carboxylic acids;Alcohols;Synthetic methods;Sulfur;Molybdenum.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	10 Jan 2010 10:58
Last Modified:	19 Sep 2010 05:53
URI:	http://eprints.iisc.ac.in/id/eprint/25290

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