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Electrophysiological correlates of hanseniasis

Ramakrishnan, AG and Srinivasan, TM (1995) Electrophysiological correlates of hanseniasis. In: International Journal of Leprosy and Other Mycobacterial Diseases, 63 (3). 395 -408.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/7594923


Sensory nerve action potentials (SNAPs) and compound nerve action potentials (CNAPs) were recorded from 25 normal subjects and 21 hanseniasis patients following electrical stimulation of the median nerve at the wrist. The various nerve conduction parameters from the affected nerves of the patients were compared with those from the clinically normal nerves of patients as well as data from healthy individuals. Analysis of the data and clinical correlation studies indicate the suitability of amplitudes of the SNAPs and CNAPs rather than the nerve conduction velocities in better characterizing the neuropathy of the patients. Significantly reduced amplitudes of responses from clinically unaffected nerves of patients indicate an early stage of neuropathy, thus being of predictive value. Further, a discriminant classifier, trained on data from clinically affected nerves of patients, classified most of the data from clinically unaffected nerves of patients as abnormal. This indicates that clinical neurophysiological studies can reveal leprous neuropathy much before it becomes clinically evident by means of sensory or motor loss. A discriminant score involving only the parameters of motor threshold, amplitude of digit potential and palm nerve conduction velocity is able to classify almost all of the normal and abnormal responses. The authors hope that further confirmative studies might ultimately lead to the use of the study of distal sensory conduction in the upper limbs in possible screening of a population exposed to Mycobacterium leprae. On the other hand, misclassification of a normal person occurred and suggests that further refinement of the methods is necessary in order to facilitate wider use of the methods under held conditions.

Item Type: Journal Article
Publication: International Journal of Leprosy and Other Mycobacterial Diseases
Publisher: Allen Press Online Publishing
Additional Information: Copy right of this article belongs to Allen Press Online Publishing.
Department/Centre: Division of Electrical Sciences > Electrical Engineering
Date Deposited: 13 Jan 2010 06:25
Last Modified: 13 Jan 2010 06:25
URI: http://eprints.iisc.ac.in/id/eprint/25207

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