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NMR and X-ray crystallographic studies on cyclic tetrapeptide, cyclo (D-Phe-Pro-Sar-Gly)

Jois, DS and Suresh, S and Vijayan, M and Easwaran, KR (1996) NMR and X-ray crystallographic studies on cyclic tetrapeptide, cyclo (D-Phe-Pro-Sar-Gly). In: International Journal of Peptide & Protein Research, 48 (1). pp. 12-20.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/8844259


The conformation of the synthetic cyclic tetrapeptide cyclo(D-Phe-Pro-Sar-Gly) has been determined in solution using the nuclear magnetic resonance technique and in the crystal state by X-ray crystallography. Results showed that the peptide exhibited two different conformations in solution, conformer 1 having cis-trans-cis-trans peptide bonds and conformer 2 having trans-cis-trans-cis peptide bonds. No intramolecular hydrogen bonds were observed in the structures. The X-ray diffraction studies showed the crystals to be orthorhombic with space group P2(1)2(1)2(1) with unit-cell dimensions, a = 5.790, b = 10.344, c = 31.446 A, Z = 4, R = 0.104 for 2301 observed reflections. The crystal structure showed only one type of conformer having cis-trans-cis-trans peptide bonds similar to the conformer 1 in solution.

Item Type: Journal Article
Publication: International Journal of Peptide & Protein Research
Publisher: Munksgaard int pub ltd
Additional Information: Copyright of this article belongs to Munksgaard int pub ltd.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 22 Jan 2010 05:24
Last Modified: 22 Jan 2010 05:24
URI: http://eprints.iisc.ac.in/id/eprint/24742

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