Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline

George, R and Ramasarma, T (1977) Nature of the stimulation of biogenesis of cholesterol in the liver by noradrenaline. In: Biochemical journal, 162 (3). pp. 493-499.

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Abstract

1.Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.

Item Type:	Journal Article
Publication:	Biochemical journal
Publisher:	Portland press
Additional Information:	Copyright of this article belongs to Portland press.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	30 Jan 2010 07:52
Last Modified:	19 Sep 2010 05:51
URI:	http://eprints.iisc.ac.in/id/eprint/24622

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