Reversible Immunocontraception in Male Monkeys Immunized with Eppin

O'Rand, MG and Widgren, EE and Sivashanmugam, P and Richardson, RT and Hall, SH and French, FS and VandeVoort, CA and Ramachandra, SG and Ramesh, V and Rao, Jagannadha A (2004) Reversible Immunocontraception in Male Monkeys Immunized with Eppin. In: Science, 306 (5699). pp. 1189-1190.

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Abstract

Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males 78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.

Item Type:	Journal Article
Publication:	Science
Publisher:	American Association for the Advancement of Science
Additional Information:	Copyright for this article belongs to American Association for the Advancement of Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	30 Mar 2005
Last Modified:	19 Sep 2010 04:17
URI:	http://eprints.iisc.ac.in/id/eprint/2456

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