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Nature of induction of tryptophan pyrrolase in cold exposure

Sitaramam, V and Ramasarma, T (1975) Nature of induction of tryptophan pyrrolase in cold exposure. In: Journal of Applied Physiology, 38 (2). pp. 245-249.

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Official URL: http://jap.physiology.org/cgi/content/abstract/38/...


The activity of hepatic tryptophan pyrrolase in rats exposed to cold increased rapidly and reached a maximum of three-fold at 8 h. On continued exposure up to 48 h stress, the activity partly decreased but remained at a level higher than the initial. Withdrawal from the cold stress reversed the change. Adrenalectomy or treatment with inhibitors of protein synthesis abolished the increase in the enzyme activity during cold stress indicating a possible involvement of corticosteroids and de novo protein synthesis. Treatment with drugs known to block autonomic nervous system failed to inhibit the cold-mediated increase in enzyme activity. The results suggest that the increase in enzyme activity obtained on cold exposure is mediated by corticosteroids and not by either indoleaklylamines or autonomic nervous system. The changes in the enzyme obtained under cold stress with respect to the overshoot phenomenon, relationship to the degree of stress and reversibility on withdrawal from the stress indicate the "adaptate" nature of the response.

Item Type: Journal Article
Publication: Journal of Applied Physiology
Publisher: The American Physiological Society
Additional Information: Copyright of this article belongs to The American Physiological Society.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 22 Jan 2010 04:37
Last Modified: 22 Jan 2010 04:37
URI: http://eprints.iisc.ac.in/id/eprint/24291

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