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Sequence-dependent molecular conformation of polynucleotides: right and left-handed helices

Sasisekharan, V and Gupta, Goutam and Bansal, Manju (1981) Sequence-dependent molecular conformation of polynucleotides: right and left-handed helices. In: International Journal of Biological Macromolecules, 3 (1). pp. 2-8.

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Based upon a stereochemical guideline, two topologically distinct types of helicalduplexes have been deduced for a polynucleotide duplex with alternating purine pyrimidine sequence (PAPP): (a) right-handed uniform (RU) helix and (b) left-handed zig-zag (LZ) helix. Both structures have trinucleoside diphosphate as the basic unit wherein the purine pyrimidine fragment has a different conformation from the pyrimidine-purine fragment. Thus, RU and LZ helices represent two different classes of sequence-dependent molecular conformations for PAPP. The conformationalf eatures of an RU helix of PAPP in B-form and three LZ-helices for B-, D- and Z-forms are discussed.

Item Type: Journal Article
Publication: International Journal of Biological Macromolecules
Publisher: Elsevier B.V.
Additional Information: Copyright of this article belongs to Elsevier B.V.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 23 Dec 2009 06:43
Last Modified: 19 Sep 2010 05:47
URI: http://eprints.iisc.ac.in/id/eprint/23876

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