Effect of the antitumor antibiotic chromomycin A3 on the humoral immune response in rats

Nayak, R and Prasad, KS and Sirsi, M (1975) Effect of the antitumor antibiotic chromomycin A3 on the humoral immune response in rats. In: Infection and Immunity, 12 (5). 943 -946.

PDF picrender.pdf - Published Version Restricted to Registered users only Download (649kB) | Request a copy

Abstract

Chromomycin A3 (250 mug/kg) suppressed the humoral immune response in rats against sheep erythrocytes when administered 48 h or later after antigenic stimulus. The antibiotic at this dose enhanced immunity when given along with or before antigen administration. The natural heterohemagglutinin levels in rabbits and guinea pigs were not affected by the antibiotic (10 mug/kg per day x 7).

Item Type:	Journal Article
Publication:	Infection and Immunity
Publisher:	American Society for Microbiology
Additional Information:	Copyright of this article belongs to American Society for Microbiology.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	22 Jan 2010 07:08
Last Modified:	19 Sep 2010 05:47
URI:	http://eprints.iisc.ac.in/id/eprint/23793

Actions (login required)

View Item