Sequence effects in structures of the dinucleotides d-pApT AND d-pTpA

Hosur, Ramakrishna V and Govi, Girjesh and Hosur, Madhusoodan V and Viswamitra, MA (1981) Sequence effects in structures of the dinucleotides d-pApT AND d-pTpA. In: Journal of Molecular Structure, 72 (Mar). pp. 261-267.

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Abstract

The H1',H2' and H2″ regions of the 270-MHz PMR spectra of two deoxydinucleotides, d-pTpA and d-pApT, have been analyzed. The coupling constants in the sugar ring indicate that both A and T sugars have a tendency to acquire 2E conformations. There is also a marginal difference in the 2E populations of the T sugar in the two dinucleotides. The trends in the chemical shifts of base protons indicate different stacking of the bases in d-pApT and d-pTpA. The sequence effects on base stacking and pentose conformation are discussed.

Item Type:	Journal Article
Publication:	Journal of Molecular Structure
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	24 Dec 2009 09:31
Last Modified:	19 Sep 2010 05:47
URI:	http://eprints.iisc.ac.in/id/eprint/23767

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