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Conformational analysis of D-pantothenic acid

Salunke, Dinakar M and Vijayan, Mamannamana (1984) Conformational analysis of D-pantothenic acid. In: Biochimica et Biophysica Acta (BBA) - General Subjects, 798, (2). pp. 180-186.

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The conformational analysis of d-pantothenic acid using classical semiempirical methods has been carried out. The pantothenic acid molecule can exist in the neutral form (I) or in the ionised form (II) with a deprotonated negatively charged carboxyl group. The neutral molecule as well as the anion is highly flexible and has an ensemble of several allowed conformations rather than one or two unique conformations. The distribution of allowed conformations indicate that the β-alanine as well as the pantoic acid part of the molecule prefers partially folded conformations. The conformation of the former is greatly affected by the ionisation state of the carboxyl group whereas that of the latter is not. Possibility of intramolecular hydrogen bonding in different allowed conformations has also been explored. A bifurcated hydrogen bond involving a carboxyl (or carboxylate) oxygen atom and a hydroxyl oxygen atom, as acceptors, and the amide nitrogen atom as the donor occurs frequently in both I and II. Amongst the two crystal structures containing pantothenic acid reported so far, the conformation of the molecule in l-lysine d-pantothenate lies in the allowed region and is stabilised by a bifurcated intramolecular hydrogen bond, whereas that in the calcium bromide salt falls in a disallowed region, presumably due to the requirement of tridentate metal coordination.

Item Type: Journal Article
Publication: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier Sceince
Additional Information: Copyright for this article belongs to Elsevier Sceince.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Jan 2010 09:34
Last Modified: 19 Sep 2010 05:47
URI: http://eprints.iisc.ac.in/id/eprint/23740

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