Nature of the activation of succinate dehydrogenase byvarious effectors and in hypobaria and hypoxia

Susheela, L and Ramasarma, T (1973) Nature of the activation of succinate dehydrogenase byvarious effectors and in hypobaria and hypoxia. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics, 292 (1). pp. 50-63.

PDF 1.pdf - Published Version Restricted to Registered users only Download (810kB) | Request a copy

Abstract

Hepatic mitochondrial succinate dehydrogenase (succinate:(acceptor)oxidoreductase, EC 1.3.99.1) was activated by preincubation of mitochondria with four diverse classes of compounds, the dicarboxylic acids, nitrophenols, quinols (and ubiquinols) and pyrophosphates. Of the various compounds tested malonate, oxaloacetate and pyrophosphate, well-known competitive inhibitors of the enzyme, and also hydroquinone and ubiquinols were effective even at low concentrations and showed maximal stimulation in 2 min.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher:	Elsevier Science
Additional Information:	Copy right of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	13 Jan 2010 04:26
Last Modified:	19 Sep 2010 05:46
URI:	http://eprints.iisc.ac.in/id/eprint/23616

Actions (login required)

View Item