Metallo crown porphyrins as ionophores-metal dependent uncoupling of mitochondrial energy potential

Dasgupta, D and Thanabal, V and Krishnan, V (1982) Metallo crown porphyrins as ionophores-metal dependent uncoupling of mitochondrial energy potential. In: Biochemical and Biophysical Research Communications, 104 (4). pp. 1427-1433.

PDF article1.pdf - Published Version Restricted to Registered users only Download (390kB) | Request a copy

Abstract

Porphyrins appended with crown ether moieties function as efficient uncouplesrs of oxidative phorphorylation in rat liver mitochondria. Permeation of these highly organized porphyrins decrease the respiratory coefficient index (RCI) values. Lowering of the RCI values parallels the number of K+ chelating crown ether groups attached to the porphyrins. The inhibitory effect upon the oxidative phorphorylation reaction depends on the nature of divalent metal ions, VO, Co, Cu and Zn in the porphyrin cavity and related to their relative tendency to complex intracellular K+ ions.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Publisher.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	14 Dec 2009 09:40
Last Modified:	19 Sep 2010 05:46
URI:	http://eprints.iisc.ac.in/id/eprint/23585

Actions (login required)

View Item