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Molecular and crystal structure of deoxyguanosine 5'-phosphate

Viswamitra, MA and Seshadri, TP (1974) Molecular and crystal structure of deoxyguanosine 5'-phosphate. In: Nature, 252 (5479). pp. 176-177.

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Official URL: http://www.nature.com/nature/journal/v252/n5479/ab...


RECENT crystallographic studies of the dinucleosides ApU (ref. 1) and GpC (ref. 2) have given experimental proof for the base pairing arrangement proposed by Watson and Crick for the DNA double helix3. Another striking feature of this structure relates to the torsional angle about the C5'-C4' bond in the phosphate−sugar backbone chain. In the Crick and Watson model4, this conformation is gauche−trans (GT). Crystal structures of 5'-nucleotides, dinucleosides and dinucleotides so far studied, however, have shown only the gauche−gauche (GG) conformation about this bond. The GG conformer is also the only one found in the refined models of the proposed structure of the double helical nucleic acids and polynucleotides5−7. The only nucleotide with a GT conformation is 6-azauridine-5'-phosphate8 which is not a normal monomer unit of nucleic acids. It is also reported that 5'-dGMP assumes preferentially GT conformation in solution9.

Item Type: Journal Article
Publication: Nature
Publisher: Macmillan Magazine Ltd
Additional Information: Copyright of this article belongs to Macmillan Magazine Ltd.
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 29 Jan 2010 07:14
Last Modified: 29 Jan 2010 07:14
URI: http://eprints.iisc.ac.in/id/eprint/23335

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