Cooperativity in the inhibition of oxidative phosphorylation by chlorophenoxyisobutyrate

Panini, SR and Kurup, CKR (1974) Cooperativity in the inhibition of oxidative phosphorylation by chlorophenoxyisobutyrate. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics, 368 (1). pp. 29-38.

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Abstract

The kinetics of inhibition of oxidative phosphorylation by the antihypercholes-terolaemic compound p-chlorophenoxyisobutyrate reveal cooperativity characteristic of allosteric interactions. Hill plots and Dixon plots give clear indication that the compound interferes with two distinct steps in the energy-transfer pathway. The values of interaction coefficients calculated from the Hill plots were two and four in the direction of ATP synthesis and one and two in the reverse direction. This could mean either that the pathways of synthesis and breakdown of ATP are different, or that if the pathways are the same, only half the inhibitor-binding sites function in the reverse direction.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	06 Oct 2009 12:39
Last Modified:	19 Sep 2010 05:45
URI:	http://eprints.iisc.ac.in/id/eprint/23333

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