Effect of LHRH agonists and antagonists in male and female bonnet monkeys (Macaca Radiata)

Rao, A Jagannadha and Chakraborti, R and Kotagi, SG and Ravindranath, N and Moudgal, NR (1985) Effect of LHRH agonists and antagonists in male and female bonnet monkeys (Macaca Radiata). In: Journal of Steroid Biochemistry and Molecular Biology, 23 (5B). 807 -809.

PDF http___www.sciencedirect.com_science__ob=MImg&_imagekey=B73GT-4RGFHWM-M-1&_cdi=11535&_user=512776&_orig=search&_coverDate=11%2F30%2F1985&_sk=999769994.7997&view=c&wchp=dGLbVtb-zSkWb&md5=f6b33d2891ba4e.pdf - Published Version Restricted to Registered users only Download (282kB) | Request a copy

Abstract

A few analogues of LHRH have been tested in the adult bonnet monkeys using change in serum testosterone following LHRH injection as a parameter of response to LHRH. Of the four analogues tested in male monkeys, Buserelin was found to be the most potent one in increasing serum testosterone levels. Injection of the LHRH antagonist at 1600 h resulted in the abolition of the characteristic nocturnal surge of testosterone observed in adult bonnet monkeys maintained under regulated light conditions. Following administration of LHRH a/s during early pregnancy, serum chorionic gonadotropin levels decreased though the course of pregnancy was not affected. These results suggest that bonnet monkey can be successfully employed to test LHRH analogues.

Item Type:	Journal Article
Publication:	Journal of Steroid Biochemistry and Molecular Biology
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	27 Jan 2010 06:10
Last Modified:	19 Sep 2010 05:44
URI:	http://eprints.iisc.ac.in/id/eprint/23122

Actions (login required)

View Item