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Interactions between Mast Cells, Fibroblasts and Connective Tissue Components

Atkins, FM and Friedman, MM and Rao, PVS and Metcalfe, DD (1985) Interactions between Mast Cells, Fibroblasts and Connective Tissue Components. In: International Archives Of Allergy And Applied Immunology, 77 (1-2). pp. 96-102.

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It has long been recognized that mast cells occur throughout connective tissues. Histologic studies have revealed that such cells release their granules into the surrounding environment upon exposure to both immunologic and nonimmunologic stimuli. By microscopy these extracellular granules appeared to be phagocytosed by fibroblasts and by blood-borne phagocytic cells as they entered the site of mast cell degranulation. Such in vivo observations led to the suggestion that mast cells both altered connective tissue components and influenced fibroblast function through these discharged granules. Recent in vitro studies using cultured fibroblasts and isolated mast cells and mast cell granules have confirmed both these hypotheses. In addition, such studies have also documented that fibroblasts degrade ingested mast cell granules. Such studies document that a number of critical interactions may occur between mast cells and connective tissue components.

Item Type: Journal Article
Publication: International Archives Of Allergy And Applied Immunology
Publisher: Karger AG, Basel
Additional Information: Copyright for this article belongs to Karger AG, Basel .
Department/Centre: Division of Electrical Sciences > Computer Science & Automation
Date Deposited: 21 Jan 2010 06:44
Last Modified: 06 Oct 2018 14:47
URI: http://eprints.iisc.ac.in/id/eprint/23099

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