Vasu, * and Nirmala, KA and Chopra, Deepak and Mohan, S and Saravanan, J (2004) Two biologically active thiophene-3-carboxamide derivatives. In: Acta Crystallographica (Section C), 60 (Part 9). O636-O638.
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Abstract
The compounds 2-{[(E)-(4-methoxyphenyl)methylene]amino}-N-(3-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, $C_{24}H_{24}N_{2}OS$, (I),and N-(4-methylphenyl)-2-{[(E)-(4-methylphenyl)methylene]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, $C_{24}H_{24}N_{2}OS$, (II), show antibacterial and antifungal activities. The m-toluidine ring in (I) and the p-toluidine ring in (II) are coplanar with their respective thiophene rings. In (I), an intermolecular C–H…O hydrogen bond is present, whereas (II)does not exhibit any significant intermolecular interactions. However, in both compounds, an intramolecular N–H…N hydrogen bond forms a pseudo-six-membered ring, thus locking the molecular conformation and eliminating conformational flexibility.
Item Type: | Journal Article |
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Publication: | Acta Crystallographica (Section C) |
Publisher: | International Union of Crystallography |
Additional Information: | The copyright belongs to International Union of Crystallography |
Department/Centre: | Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
Date Deposited: | 06 Dec 2004 |
Last Modified: | 19 Sep 2010 04:17 |
URI: | http://eprints.iisc.ac.in/id/eprint/2308 |
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