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Specificity of protein - Nucleic acid interaction and the biochemical evolution

Podder, SK and Basu, HS (1984) Specificity of protein - Nucleic acid interaction and the biochemical evolution. In: Origins of Life and Evolution of Biospheres, 14 (1-4). pp. 477-484.

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The water soluble carbodiimide mediated condensation of dipeptides of the general form Gly-X was carried out in the presence of mono- and poly-nucleotides. The observed yield of the tetrapeptide was found to be higher for peptide-nucleotide system of higher interaction specificity following mainly the anticodon-amino acid relationship (Basu, H.S. & Podder, S.K., 1981, Ind. J. Biochem. Biophys.,19, 251-253). The yield of the condensation product of L-peptide was more because of its higher interaction specificity. The extent of the racemization during the condensation of Gly-L-Phe, Gly-L-Tyr and Gly-D-Phe was found to be dependent on the specificity of the interaction -the higher the specificity, the lesser the racemization. The product formed was shown to have a catalytic effect on the condensation reaction. These data thus provide a mechanism showing how the specific interaction between amino acids/dipeptides and nucleic acids could lead to the formation of the lsquoprimitiversquo translation machinery.

Item Type: Journal Article
Publication: Origins of Life and Evolution of Biospheres
Publisher: Springer
Additional Information: Copyright for this article belongs to Springer.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 29 Jan 2010 06:12
Last Modified: 19 Sep 2010 05:43
URI: http://eprints.iisc.ac.in/id/eprint/22884

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