Hormonal induction of riboflavin carrier protein in the chicken oviduct and liver: a comparison of kinetics and modulation

DurgaKumari, B and Adiga, Radhakantha P (1986) Hormonal induction of riboflavin carrier protein in the chicken oviduct and liver: a comparison of kinetics and modulation. In: Molecular and Cellular Endocrinology, 44 (3). 285-292.

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Abstract

Estrogen (E) induction of riboflavin carrier protein (RCP) in the chicken oviduct and liver was investigated to compare and contrast the kinetics, hormonal specificity and modulation of its elaboration in the 2 steroid-responsive tissues. During primary stimulation, continued daily E administration to immature female chicks elicited, after an initial lag, rapid growth and RCP content of the oviduct; neither progesterone (P) nor testosterone (T) could substitute for E in this respect. Furthermore, P given along with E curtailed tissue growth and its RCP content, whereas E + T had a synergistic effect on tissue growth only. During secondary stimulation, E administration steeply enhanced both tissue weight and RCP content without any lag. Interestingly, P (but not T) could substitute for E in augmenting magnum RCP concentration to a comparable extent while a concomitant effect on tissue growth was less marked. In contrast, hepatic induction of RCP was absolutely E-specific during both primary and secondary stimulations. Secondary stimulation with either E or P of E-primed birds enhanced the rates of RCP synthesis in the oviduct relative to that of total protein, whereas in the liver only E was effective in this regard. The absolute rate of E-induced RCP synthesis in both the steroid-stimulated tissues was significantly higher than that of general protein elaboration.

Item Type:	Journal Article
Publication:	Molecular and Cellular Endocrinology
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	radioimmunoassay;gene expression;comparison estrogen; progesterone;testosterone;primary stimulation;secondary stimulation;modulation.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	31 Aug 2009 04:46
Last Modified:	29 Feb 2012 08:40
URI:	http://eprints.iisc.ac.in/id/eprint/22601

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