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The scale-invariance of spatial patterning in a developing system

Lokeshwar, L Balakrishna and Nanjundiah, Vidyanand (1981) The scale-invariance of spatial patterning in a developing system. In: Wilhelm Roux's Archives of Developmental Biology, 190 (6). pp. 361-364.

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Regulating systems, that is, those which exhibit scale-invariant patterns in the adult, are supposed, to do so on account of interactions between cells during development. The nature of these interactions has to be such that the system of positional information (ldquomaprdquo) in the embryo also regulates. To our knowledge, this supposition regarding a regulating map has not been subjected to a direct test in any embryonic system. Here we do so by means of a simple and novel criterion and use it to examine tip regeneration in the mulicellular stage (slug) ofDictyostelium discoideum. When anterior, tip-containing fragments of slugs are amputated, a new tip spontaneously regenerates at the cut surface of the (remaining) posterior fragment. The time needed for regeneration to occur depends on the relative size of the amputated fragment but is independent of the total size of the slug. We conclude from this finding that there is at least one system underlying positional information in the slug which regulates.

Item Type: Journal Article
Publication: Wilhelm Roux's Archives of Developmental Biology
Publisher: springer
Additional Information: Copy right of this article belongs to springer.
Keywords: Regulation - Positional Information - Regeneration - Dictyostelium
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 18 Jan 2010 06:43
Last Modified: 19 Sep 2010 05:42
URI: http://eprints.iisc.ac.in/id/eprint/22535

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