Adriamycin affects plasma membrane redox functions

Crane, FL and MacKellar, WC and Morre, DJ and Ramasarma, T and Goldenberg, H and Grebing, C and Low, H (1980) Adriamycin affects plasma membrane redox functions. In: Biochemical and Biophysical Research Communications, 93 (3). pp. 746-754.

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Abstract

Adriamycin (Doxorubicin) stimulates NADH oxidase activity in liver plasma membrane, but does not cause NADH oxidase activity to appear where it is not initially present, as in erythrocyte membrane. NADH dehydrogenase from rat liver and erythrocyte plasma membranes shows similar adriamycin effects with other electron acceptors. Both NADH ferricyanide reductase and vanadate-stimulated NADH oxidation are inhibited by adriamycin, as is a cyanide insensitive ascorbate oxidase activity, whereas NADH cytochrome c reductase is not affected. The effects may contribute to the growth inhibitory (control) and/or deleterious effects of adriamycin. It is clear that adriamycin effects on the plasma membrane dehydrogenase involve more than a simple catalysis of superoxide formation.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	20 Aug 2009 10:42
Last Modified:	19 Sep 2010 05:42
URI:	http://eprints.iisc.ac.in/id/eprint/22482

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