Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia

Wootla, Bharath and Mahendra, Ankit and Dimitrov, Jordan D and Friboulet, Alain and Borel-Derlon, Annie and Rao, Desirazu N and Uda, Taizo and Borg, Jeanne-Yvonne and Bayry, Jagadeesh and Kaveri, Srinivas V and Lacroix-Desmazes, Sebastien (2009) Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia. In: FEBS Letters, 583 (15). pp. 2565-2572.

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Abstract

Anti-factor VIII (FVIII) inhibitory IgG may arise as alloantibodies to therapeutic FVIII in patients with congenital hemophilia A, or as autoantibodies to endogenous FVIII in individuals with acquired hemophilia. We have described FVIII-hydrolyzing IgG both in hemophilia A patients with anti-FVIII IgG and in acquired hemophilia patients. Here, we compared the properties of proteolytic auto- and allo-antibodies. Rates of FVIII hydrolysis differed significantly between the two groups of antibodies. Proline-phenylalanine-arginine-methylcoumarinamide was a surrogate substrate for FVIII-hydrolyzing autoantibodies. Our data suggest that populations of proteolytic anti-FVIII IgG in acquired hemophilia patients are different from that of inhibitor-positive hemophilia A patients.

Item Type:	Journal Article
Publication:	FEBS Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Catalytic antibody;Acquired hemophilia;Hemophilia A;FVIII inhibitor;Factor VIII;PFR-MCA.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	26 Aug 2009 04:52
Last Modified:	19 Sep 2010 05:42
URI:	http://eprints.iisc.ac.in/id/eprint/22457

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