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Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene

Kumar, P Sai and Kurup, CK Ramakrishna (1984) Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics, 766 (1). pp. 263-266.

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The azodye 2-methyl-4-dimethylaminoazobenzene inhibited oxidation and phosphorylation in tightly coupled rat liver mitochondria. Phosphorylation was more sensitive to the inhibitory action of the azodye than was the oxidation of succinate or ascorbate. The oxidation of NAD+-linked substrate was severely inhibited by the compound. In submitochondrial particles, only NADH oxidation was sensitive. The site of inhibition has been identified to lie between the dehydrogenase flavoprotein and ubiquinone.

Item Type: Journal Article
Publication: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier Science
Additional Information: Copyright for this article belongs to Elsevier Science.
Keywords: Oxidative phosphorylation; Respiratory chain; Electron transport inhibitor; Azodye; 2-Methyl-4-dimethylaminoazobenzene; (Rat liver mitochondria).
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 25 Aug 2009 09:59
Last Modified: 19 Sep 2010 05:41
URI: http://eprints.iisc.ac.in/id/eprint/22352

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