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p53 and little brother p53/47: linking IRES activities with protein functions

Grover, R and Candeias, MM and Fahraeus, R and Das, S (2009) p53 and little brother p53/47: linking IRES activities with protein functions. In: Oncogene, 28 (30). pp. 2766-2772.

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The tumor suppressor p53 represents a paradigm for gene regulation. Its rapid induction in response to DNA damage conditions has been attributed to both increased half-life of p53 protein and also increased translation of p53 mRNA. Recent advances in our understanding of the post-transcriptional regulation of p53 include the discovery of internal ribosome entry sites (IRESs) within the p53 mRNA. These IRES elements regulate the translation of the full length as well as the N-terminally truncated isoform, p53/47. The p53/47 isoform is generated by alternative initiation at an internal AUG codon present within the p53 ORF. The aim of this review is to summarize the role of translational control mechanisms in regulating p53 functions. We discuss here in detail how diverse cellular stress pathways trigger alterations in the cap-dependent and cap-independent translation of p53 mRNA and how changes in the relative expression levels of p53 isoforms result in more differentiated p53 activity.

Item Type: Journal Article
Publication: Oncogene
Publisher: Nature publication group
Additional Information: copyright of this article belongs to Nature publication group.
Keywords: p53; p53/47; IRES; translational control
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 23 Dec 2009 09:09
Last Modified: 19 Sep 2010 05:41
URI: http://eprints.iisc.ac.in/id/eprint/22259

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