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Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria

Swaroop, A and Ramasarma, T (1985) Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria. In: Biochemical Journal, 226 (2). pp. 403-408.

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Exposure of rats to heat (39 +/- 1 degree C) decreased H2O2 generation in mitochondria of the liver, but not of the kidney or the heart. The effect was obtained with three substrates, succinate, glycerol 1-phosphate and choline, with a decrease to 50% in the first 2-3 days of exposure, and a further decrease on longer exposure. The dehydrogenase activity with only glycerol 1-phosphate decreased, which is indicative of the hypothyroid condition, whereas choline dehydrogenase activity remained unchanged and that of succinate dehydrogenase decreased on long exposure. The serum concentration of thyroxine decreased in heat-exposed rats. Thyroxine treatment of rats increased H2O2 generation. Hypothyroid conditions obtained by treatment with propylthiouracil or thyroidectomy caused a decrease in H2O2 generation and changes in dehydrogenase activities similar to those with heat exposure. Treatment of heat-exposed or thyroidectomized rats with thyroxine stimulated H2O2 generation by a mechanism apparently involving fresh protein synthesis. The results indicate that H2O2 generation in mitochondria of heat-exposed animals is determined by thyroid status.

Item Type: Journal Article
Publication: Biochemical Journal
Publisher: Biochemical Society, London
Additional Information: The copyright of this article belongs to Biochemical Society, London.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Aug 2009 10:47
Last Modified: 19 Sep 2010 05:40
URI: http://eprints.iisc.ac.in/id/eprint/22052

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