A hexokinase effect in the inhibition of oxidative phosphorylation in heart muscle mitochondria by Adriamycin

Muhammed, H and Ramasarma, T and Kurup, CK Ramakrishna (1982) A hexokinase effect in the inhibition of oxidative phosphorylation in heart muscle mitochondria by Adriamycin. In: Biochemical and Biophysical Research Communications, 105 (4). 1440 -1445.

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Abstract

The inhibitory action of the anticancer antibiotic, Adriamycin, on succinate-dependent oxidative phosphorylation in heart mitochondria was markedly potentiated by the presence of hexokinase in the reaction medium. This 'hexokinase effect' was not observed in the oxidation of NAD+-linked substrates, or when liver or kidney mitochondria were used in place of heart mitochondria. These results offer a biochemical explanation for the extreme cardiac toxicity of the drug.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	27 Jul 2009 16:35
Last Modified:	19 Sep 2010 05:38
URI:	http://eprints.iisc.ac.in/id/eprint/21759

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