Inhibition of mitochondrial oxidative phosphorylation by adriamycin

Muhammed, H and Ramasarma, T and Kurup, CKR (1983) Inhibition of mitochondrial oxidative phosphorylation by adriamycin. In: Biochimica et Biophysica Acta (BBA), 722 (1). pp. 43-50.

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Abstract

The antitumour antibiotic, adriamycin, inhibited oxidative phosphorylation in freshly prepared mitochondria from the heart, liver and kidney of the rat. It abolished respiratory control and stimulated ATPase activity. Sccinate oxidation by heart mitochondria was extremely sensitive to the drug when hexokinase was present in the reaction medium. The sensitive site has been identified to lie in the region between the succinate dehydrogenase flavoprotein and ubiquinone of the respiratory chain.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta (BBA)
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	25 Aug 2009 10:02
Last Modified:	19 Sep 2010 05:38
URI:	http://eprints.iisc.ac.in/id/eprint/21541

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