Devi, AR and Rao, NA and Bittles, AH (1987) Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. In: Journal of Medical Genetics, 24 (6). 362 -365.
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Abstract
Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool.
Item Type: | Journal Article |
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Publication: | Journal of Medical Genetics |
Publisher: | BMJ Publishing Group |
Additional Information: | Copy right of this article belongs to BMJ Publishing Group |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 21 Aug 2009 05:33 |
Last Modified: | 19 Sep 2010 05:36 |
URI: | http://eprints.iisc.ac.in/id/eprint/21182 |
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