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Expression of Cytochrome P-450 and Albumin Genes in Rat Liver: Effect of Xenobioticst

Satyabhama, S and Seelan, R Sathiagnana and Padmanaban, G (1986) Expression of Cytochrome P-450 and Albumin Genes in Rat Liver: Effect of Xenobioticst. In: Biochemistry, 25 (16). pp. 4508-4512.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/bi00364a009


Thioacetamide, a hepatocarcinogen and an inhibitor of heme synthesis, blocks the phenobarbitone- mediated increase in the transcription of cytochrome P-450b+e messenger RNA in rat liver. This property is also shared by CoCl, and 3-amino-l,2,4-triazole, two other inhibitors of heme synthesis. Thus, it appears feasible that heme may serve as a positive regulator of cytochrome P-450b+e gene transcription. Thioacetamide enhances albumin messenger RNA concentration, whereas phenobarbitone decreases the same. However, these changes in albumin messenger RNA concentration are not accompanied by corresponding changes in the transcription rates. Therefore, drug-mediated changes in albumin messenger RNA concentration are due to posttranscriptional regulation. The property of thioacetamide to enhance the albumin messenger RNA concentration is not shared by CoC1, and 3-amino- 1,2,4-triazole. Therefore, heme does not appear to be a regulatory molecule mediating the reciprocal changes brought about in the concentrations of cytochrome P-450b+e and albumin messenger RNAs.

Item Type: Journal Article
Publication: Biochemistry
Publisher: American Chemical Society
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 19 Jul 2009 06:28
Last Modified: 19 Sep 2010 05:35
URI: http://eprints.iisc.ac.in/id/eprint/21021

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