Structure of 2',3'-O-Isopropylidene-5'-O-tosyluridine, C19H22N 2Oas

Gautham, N and Seshadri, TP and Viswamitra, MA and Sslisbury, SA (1983) Structure of 2',3'-O-Isopropylidene-5'-O-tosyluridine, C19H22N 2Oas. In: Acta Crystallographica Section C, 39 (4). pp. 459-461.

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Abstract

M r = 438.45, trigonal, P32, a = b = 13.385 (4), c = 9.900 (5) A,, V = 1536.0 A 3, Z = 3, D x = 1.42, D m = 1.42 Mg m -3, 2(Cu Ka) = 1.5418 A,,g(CuKa) = .800mm -], T=290K, F(000)=690, R=6.0% for 1222 unique reflections with F o>_2o(Fo). This is the first 2',3'-O-isopropylidene pyrimidine nucleoside with the base in a syn orientation with respect to the ribose [Xcy= 116.0(7)°]. The ribose has a C(3')-endo conformation with the phase angle of pseudorotation P = 16.36 (2) °. The dioxolane ring assumes an envelope conformation with 0(2') displaced from the best four-atom plane by 0.50 (1) k. The crystal structure is possibly stabilized by a bifurcated hydrogen bond between N(3) and the 0(2) and 0(4) atoms of screw-related molecules.

Item Type:	Journal Article
Publication:	Acta Crystallographica Section C
Publisher:	International Union of Crystallography
Additional Information:	Copyright of this article belongs to International Union of Crystallography.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	04 Feb 2010 05:12
Last Modified:	19 Sep 2010 05:34
URI:	http://eprints.iisc.ac.in/id/eprint/20823

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