Hantzsch 1,4-dihydropyridine esters and analogs: candidates for generating reproducible one-dimensional packing motifs

Rathore, RS and Reddy, B Palakshi and Vijayakumar, V and Ragavan, R Venkat and Narasimhamurthy, T (2009) Hantzsch 1,4-dihydropyridine esters and analogs: candidates for generating reproducible one-dimensional packing motifs. In: Acta Crystallographica Section B, 65 (Part 3). pp. 375-381.

PDF fulltext.pdf - Published Version Restricted to Registered users only Download (607kB) | Request a copy

Abstract

Examination of the symmetric Hantzsch 1,4-dihydropyridine ester derivatives of the prototypical nifedipine molecule indicates the tendency of this class of molecule to form a common packing motif. Crystal structure analysis of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic diesters and analogs reveals that they form extended chains, characterized as the C(6) packing motif, via intermolecular (amine) N-H...O=C (C3,C5 carbonyl) hydrogen bonds. In addition, all the prepared derivatives also satisfy the basic structural requirements for their high binding efficiency to the receptor. The reproducible C(6) packing motif observed among these compounds has a use in the design of solid-state materials.

Item Type:	Journal Article
Publication:	Acta Crystallographica Section B
Publisher:	International Union of Crystallography
Additional Information:	Copyright of this article belongs to International Union of Crystallography.
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	23 Jul 2009 09:58
Last Modified:	19 Sep 2010 05:34
URI:	http://eprints.iisc.ac.in/id/eprint/20742

Actions (login required)

View Item