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Molecular insights into the causes of male infertility

Seshagiri, Polani B (2001) Molecular insights into the causes of male infertility. In: Journal of Biosciences, 26 (4). pp. 429-435.


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Infertility is a reproductive health problem that affects many couples in the human population. About 13–18% of couple suffers from it and approximately one-half of all cases can be traced to either partner. Regardless of whether it is primary or secondary infertility, affected couples suffer from enormous emotional and psychological trauma and it can constitute a major life crisis in the social context. Many cases of idiopathic infertility have a genetic or molecular basis. The knowledge of the molecular genetics of male infertility is developing rapidly, new spermatogenic genes are being discovered and molecular diagnostic approaches (DNA chips) established. This will immensely help diagnostic and therapeutic approaches to alleviate human infertility. The present review provides an overview of the causes of human infertility, particularly the molecular basis of male infertility and its implications for clinical practice.

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy Sciences
Additional Information: Copyright for this article belongs to Indian Academy Sciences.
Keywords: Fertility genes;infertility;medically assisted reproductive technology;Y-chromosome
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 22 Aug 2008
Last Modified: 19 Sep 2010 04:16
URI: http://eprints.iisc.ac.in/id/eprint/2029

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